Publications


ORIGINAL PEER-REVIEWED ARTICLES

1. Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro Oncology, 13(7)725-35, 2011 Download
2. Emdad L, D'Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, Jul 26, 2011 [Epub ahead of print] Download
3. Binello E and Germano IM. Stem cells and brain tumors: from Therapeutic targets to therapeutic vehicles. Cancer Sci, Aug 16, 2011 [Epub ahead of print] Download
4. Lehrer S, Lombardi V, Green S, Pessin-Minsley MS, Germano IM, Rosenzweig KE. No circulating cytomegalovirus in five patients with glioblastoma multiforme. Anticancer Res 31(3)959-60, 2011 Download
5. Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. A stem-cell enriched brain tumor model in the immunocompetent mouse: characterization for pre-clinical testing. Neuro Oncology, In Press, 2011 Download
6. Binello E and Germano IM. Stem cells as therapeutic vehicles for the treatment of gliomas. J Neuro-Oncol, In Press, 2011
7. Roberts CC, Fitzgerald JJ, Daffner RH, Weissman BN, Apple M, Bancroft L, Bennet DL, Bllebea JS, Bruno MA, Fries IB, Germano IM, Hayes CW, Holly L, Kransdorf MJ, Luchs JS, Morrison WB, Olson J, Scharf SC, Stoller DW, Taljanovic MS, Tuite MJ, Ward RJ, Wise JN, Zoga AC. Follow-up on malignant or aggressive muscoloscheletal Tumors. J Rad Onc Biol Phys, In press 2011 Download
8. Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 Download
9. Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) -mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664-74, 2010 Download
10. Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries BI, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnik CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz, ST. Metastatic bone disease, ACR Appropriateness Criteria topic. J Am Coll Radiol Jun;7(6):400-409, 2010 Download
11. Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro-pharmacology 58(6):903-10, 2010 Download
12. Wippold FJ 2nd and Expert Panel on Neurologic Imaging (Germano IM). Orbits, vision, and visual loss. Am J Neuroradiol. 31(1):196-8, 2010 Download
13. Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009 Download
14. Germano IM and Binello E. Gene therapy for adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009 Download
15. Binello E and Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neurooncol 93:79-87, 2009 Download
16. Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009 Download
17. Gonzales A, Sullivan g, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano IM, Mullen M, Simpson D. Inflammatory Pseutotumor associated with HIV-JCV an immune-reconstruction syndrome. Neurology 72:287-290, 2009 Download
18. Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008 Download
19. Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 7:81-7, 2008 Download
20. Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651,2007 Download
21. Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006 Download
22. Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005 Download
23. Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005 Download
24. Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005 Download
25. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. Download
26. Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004 Download
27. Kanzawa T, Germano IM, Komata T, ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11(4) 448-457, 2004 Download
28. Morrison CE, Borod JC, Perrine K, Beric A, Brin MF, Rezai A, Kelly P, Sterio D, Germano IM, Weisz D, Olanow CW. Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson's disease. Arch Clin Neuropsychol 19(2):165-81, 2004 Download
29. Kanzawa T, Bedwell J, Kondo Y, Kondo S, Germano IM. Inhibition of DNA repair sensitizes resistant glioma cells to temozolomide. J Neurosurgery 99:1047-1052, 2003 Download
30. Germano IM, Fable J, Gultekin H, Silvers A. Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas. J Neuro-Oncology 65:279-289, 2003 Download
31. Kanzawa T, Komata T, Kyo S, Germano IM, Kondo Y, Kondo S. Down-regulation of telomerase acitivity in malignant glioma cells by p27k1p1. J Oncol 23:1703-8, 2003 Download
32. Kanzawa T, Germano IM, Kondo Y,Ito H, Kyo S, Kondo S. inhibition of telomerase activity in malignant glioma cell lines correlates with their sensitivity to TMZ. Br J Cancer 189:922-929, 2003 Download
33. Kanzawa T, Kondo Y, Ito I, Kondo S, Germano IM. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Research 63:2103-2108, 2003 Download
34. Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S. Antitumor effect of cyclin-dependent kinase inhibitors (p16, p18, p19, p21, and p27) on malignant glioma cells. British Journal of Cancer 88:1277-1280, 2003 Download
35. Yao K, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma cells to ionizing radiations: cell cycle arrest, CDKI modulation, and autophagy. J Neurosurgery 98:378-384, 2003 Download
36. Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S. Antitumor effect of cyclin-dependent kinase inhibitors (p16INK4A, p18INK4C, p19INK4D, p21WAFI/CIPI and p27KIPI) on malignant glioma cells. British Journal of Cancer 88:1277-80, 2003. Download
37. Benveniste R and Germano IM. Evaluation of factors predicting accurate resection of high-grade gliomas using frameless image-guided sterotactic guidance. Neurosurgical Focus 14:1-4, 2003 Download
38. Komata T, Kondo Y, Kanzawa T, Ito H, Satoshi H, Koga S, Sumiyoshi H, Takakura M, Inoue M, Barna B, Germano IM, Kyo S, Kondo S. Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells. Human Gene Therapy 13:1015-1025, 2002 Download
39. Komata T, Koga S, Hiroata S, Takamura M, Germano IM, Inoue M, Kyo S, Kondo S, Kondo Y. A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. Int J Oncol 19:1015-1020, 2001 Download
40. Germano IM, Weisz DJ, Silvers A, Shrivastava R, Yang BY. Surgical techniques for stereotactic implant of deep brain stimulators. Seminars in Neurosurgery 12:213-223, 2001 Download
41. The deep-brain stimulation for Parkinson's disease study group. Deep brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med, 345:956-963, 2001 Download
42. Komata T, Kondo Y, Kanzawa T, Hirohata S, Koga S, Sumiyoshi H, Srinivasula SM, Barna BP, Germano IM, Takakura M, Inoue M, Alnemri ES, Shay JW, Kyo S, Kondo S. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human reverse transcriptase) gene promoter. Cancer Res 61:5796-5802, 2001 Download
43. Walker RH, Danisi FO, Swope DM, Goodman RR, Germano IM, Brin MF. Intrathecal baclofen for dystonia: benefits and complications during six years experience. Movement Disorders 15:1242-1247, 2000 Download
44. Morrison CE, Borod JC, Brin MF, Raskin SA, Germano IM, Weisz DJ, Olanow CW. A program for neurophysiological investigation of deep brain stimulation (PNIDBS) in movement disorder patients: development, feasibility, and preliminary data. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 13(3): 204-219, 2000 Download
45. Sperber EF, Veliskova J, Germano IM, Friedman LK, Moshe' SL. Age-dependent vulnerability to seizures. Adv Neurol 79:161-169, 1999 Download
46. Germano IM, Villalobos H, Silvers A, Post K. Clinical Use of the Neurostation for Intracranial Computer-Assisted Neuronavigation. Neurosurgery 45:261-270,1999 Download
47. Villalobos H and Germano IM. Clinical evaluation of multimodality registration in frameless stereotaxy. Computer Aided Surgery 4:45-49, 1999 Download
48. Germano IM, Sperber EF, Ahuja S, Moshe SL. Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders. Epilepsia 39:1253-1260,1998 Download
49. Germano IM and Queenan JV. The optical digitizer for interactive, image-guided brain needle biopsy in 16 cases. Computer Aided Surgery, 3:33-39, 1998 Download
50. Germano IM and Sperber EF. Transplacentally induced neuronal migration disorders: an animal model for the study of the epilepsies. J Neuroscience Research J Neuroscience Research, 51:473-488, 1998 Download
51. Ahuja S and Germano IM. Anticonvulsant and neuronal protective effects of propofol on experimental status epilepticus. J Epilepsy, 11:168-176, 1998 Download
52. Germano IM and Sperber EF. Increased seizure susceptibility in adult rats with neuronal migration disorders. Brain Research, 777:219-222, 1997 Download
53. Segal DH, Germano IM, Bederson JB. Effects of basic fibroblast growth factor on in vivo cerebral tumorigenesis. Neurosurgery 40:1027-1033, 1997 Download
54. Lorberboym M, Mandel LR, Mosesson RE, Germano IM, Lou W, DaCosta M, Linzer DG, Macha J. The role of thallium-201 uptake and retention in intracranial tumor after radiotherapy. J Nucl Med 38:223-226, 1997 Download
55. Germano IM. Trans-sulcal approach to mesiotemporal lesions: anatomy and technique. Neurosurgical Focus 1(5):1-12, 1996 Download
56. Brisman M, Bederson J, Germano IM, Sen, C, Moore F, Post K. Intracerebral hemorrhage remote form craniotomy site. Neurosurgery, 39:1114-1122, 1996 Download
57. Germano IM, Zhang YF, Sperber EF, Moshe SL. Neuronal migration disorders increase the susceptibility to hyperthermia-induced seizures in the rat. Epilepsia, 37(9):902-910, 1996 Download
58. Lorberboym M, Estok L, Machac J, Germano IM, Sacher M, Feldman R, Wallach F, Dorfman D. Rapid differential diagnosis of cerebral toxoplasmosis and primary CNS lymphoma by thallium-201 SPECT. J Nuclear Med, 37:1150-1154, 1996 Download
59. Mandell LR, Lorberboym M, Mosesson R, Germano IM, Linzer D, Tabert A, DeWyngaert JK. Preliminary results of thallium-201 SPECT scanning in the postradiosurgery management of malignant brain tumors: a step closer toward clinical histopathologic interpretation. Radiosurgery, 1:113-126, 1996 Download
60. Shiau J and Germano IM. Gadopentetate-induced status epilepticus. J Epilepsy, 8:306-308, 1995 Download
61. Bederson JB, Germano IM, Guarino L. Cortical blood flow and cerebral perfusion pressure in a new non-craniotomy model of subarachnoid hemorrhage in the rat. Stroke, 26:1086-1092, 1995 Download
62. Germano IM. The Neuro-station system for image-guided frameless stereotaxy. Neurosurgery, 37:348-350, 1995 Download
63. Olivier A, Germano IM, Cukiert A, Peters T. Frameless stereotaxy for surgery of the epilepsies. J Neurosurg, 81:629-633, 1994 Download
64. Germano IM, Poulin N, Olivier A. Re-operation for temporal lobe epilepsy. J Neurosurg, 80:31-36, 1994 Download
65. Germano IM, Edwards M, Davis RL, Schiffer D. Intracranial meningiomas of the first two decades of life. J Neurosurg, 80;447-453, 1994 Download
66. Germano IM, Davis RL, Wilson CB, Hieshima GB. Histopathological Follow-up of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol. J Neurosurg, 76:607-614, 1992 Download
67. Cohen Y, Chang LH, Litt L, Kim F, Severinghaus JW, Weinstein PR, Davis RL, Germano IM, James TL. Stability of brain intracellular lactate and 31P-metabolite levels at reduced intracellular pH during prolonged hypercapnia in rats. J Cereb Blood Flow Metab, 10: 277-284, 1990 Download
68. Germano IM, Ito M, Cho K, Hoshino T, Davis R, Wilson C. Correlation of histopathological features and proliferative potential of individual gliomas. J Neurosurg, 70:701-706, 1989 Download
69. Germano IM, Pitts L, Berry I, Moseley M. Magnetic resonance imaging (MRI) and spectroscopy (MRS) for evaluating focal cerebral ischemia. J Neurosurg, 70:612-618, 1989 Download
70. Germano IM, Pitts L, Berry I, DeArmond S. High energy phosphate metabolism in experimental permanent focal cerebral ischemia: An in vivo 31P magnetic resonance spectroscopy study. J Cereb Blood Flow Metab, 8:24-31, 1988 Download
71. Germano IM, Pitts L, Meldrum B, Bartkowksi H, Simon R. Kynurenate inhibition of cell excitation decreases stroke size and deficits. Ann Neurol, 22:730-734, 1987 Download
72. Germano IM, Bartkowski H, Cassel M, Pitts L. The therapeutic value of nimodipine in experimental focal cerebral ischemia: Neurological outcome and neuropathological findings. J Neurosurg, 67:81-87, 1987 Download
73. Schiffer D, Giordana MT, Germano IM, Mauro A. Anaplasia and heterogeneity of GFAP expression in gliomas. Tumori, 72: 163-170, 1986 Download
74. Bederson J, Pitts L, Germano IM, Nishimura M, Davis R, Bartkowksy H. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke, 17:1304-1308, 1986 Download
75. Schiffer D, Giordana MT, Mauro A, Migheli A, Germano IM, Giaccone G. Immunohistochemical demonstration of vimentin in human cerebral tumors. Acta Neuropath, 70:209-219, 1986 Download
76. Germano IM, Bartkowski HM, Berry I, Moseley M, Brant-Zawadski M, Pitts L: Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia. Acta Radiol, S369:49-52, 1986 Download
77. Berry I, Moseley M, Germano IM, Ishige N, Nishimura M, Bartkowski H, Pitts L, Brant-Zawadski M:. Combined magnetic resonance imaging and spectroscopy in experimental regional injury of the brain. Acta Radiol, S369:338-349, 1986 Download
78. Mauro A, Germano IM, Giaccone G, Giordana G, Mauro A, Micheli A, Schiffer D. 1-naphthol-basic dye (1NBD): An alternative to diaminobenzodiazepine in immunoperoxidase techniques. Histochemistry, 83:97-102, 1985 Download
79. Giordana MT, Germano IM, Giaccone G, Mauro A, Migheli A, Schiffer D. The distribution of laminin in human brain tumors: An immunohistochemical study . Acta Neuropath, 67:51-57, 1985 Download
80. Mauro A, Bertolotto A, Germano IM, Giaccone G, Giordana MT, Migheli A, Schiffer D. Collagenase in the immunohistochemical demonstration of laminin, fibronectin, and factor VIII/RAg in nervous tissue after fixation. Histochemistry, 80:157-163, 1984 Download
81. Germano IM. Immunohistochemistry of the central nervous system: The neuroepithelial markers. 1-134, Turin Medical Press, Turin 1984
82. Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency room-bases study patter and outcome of neurologicall and neurosurgical diseases in Haiti. World Neurosurg. 2013 Oct 9. S1878-8750(13)01298-9. [Epub ahead of print] Download
83. McCormick PJ, Osborn IP, Germano IM, Green S, Deiner SG. Scalp nerve blockade reduces pain after headframe placement in radiosurgery: a double blind, randomized clinical trial. Middle East J Anesthesiol. 2013 Feb;22(1):79-85 Download
84. Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A immunocompetent Mouse Brain Mode. Journal of Cancer, 3:166-174, 2012 Download
85. Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade glioma. Neuro Oncol, 14:256-265, 2012 Download
86. Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012
87. Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surgical Neurology Int, 3:118-126, 2012
88. Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012 Download
89. Binello E and Germano IM. Targeting glioma stem cells: A novel frame work for brain tumors. Cancer Sci, 102:1958-1966, 2011 Download
90. Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro Oncology, 13(7)725-35, 2011 Download
91. Lehrer S, Lombardi V, Green S, Pessin-Minsley MS, Germano IM, Rosenzweig KE. No circulating cytomegalovirus in five patients with glioblastoma multiforme. Anticancer Res 31(3)959-60, 2011 Download